| 摘要 |
The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): <IMAGE> (I) wherein R represents -CH=CH(CH2)nCH3 or -CH2CH2(CH2)nCH3; n is 12 or 14; R1 represents <IMAGE> <IMAGE> or hydrogen; and R2 represents hydrogen or acetyl; for use in therapy. The compounds are useful as inhibitors of phospholipases A2, and of superoxide production, as antiproliferative and immunosuppressant agents and in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.
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