| 摘要 |
PURPOSE:To represent temporal variation of the concentration of drug or metabolite thereof in humor including blood accurately by approximating the temporal variation of the concentration of a labeled body, e.g. a drug, using a function shown by a specific formula CONSTITUTION:A drug, a poison, or a substrate is given to an animal and the temporal variation of the concentration of the substance and/or the metabolite thereof in humor, e.g. blood, is measured in order to analyze metabolism in the body of the animal. Temporal variation of concentration Cp in the humor is approximated by a function; Y=Aexp(-k1t)+B(1-exp(-k1t))-(1-exp(-k2t)exp(-k3t), or Y=A(exp(-k1t)+b-(1-exp(-k1t))-(l-exp(-k2t))exp(-k3t)). In the formula, (t) represents the time to be elapsed after dosage, and A, B, b, k1, k2, k3 represent constants. The analysis method can be applied to phleboclysis, endoceliac injection, or oral dispensation, and especially useful for phleboclysis.
|
