发明名称 |
Recombinant chimeric proteins deliverable across cellular membranes into cytosol of target cells |
摘要 |
Proteins that are impermeable and foreign to the eukaryotic cells can now be delivered across cellular membranes into the cytosol of target cells by making a chimeric protein having specific attributes. A method of making such chimeric proteins is disclosed. As an example, a chimeric protein PE-Bar with dual enzymatic activity has been made. The chimeric proteins can be used for cytotoxic, diagnostic or therapeutic purposes, such as for compensating the deficiency or defect of an enzyme or a protein which may be causative of a disease or an abnormality.
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申请公布号 |
US5328984(A) |
申请公布日期 |
1994.07.12 |
申请号 |
US19910663455 |
申请日期 |
1991.03.04 |
申请人 |
THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES |
发明人 |
PASTAN, IRA H.;TREVOR, PRIOR;FITZGERALD, DAVID J.;DEBINSKI, WALDEMAR;SIEGALL, CLAY |
分类号 |
C07K14/21;C07K14/495;C12N9/54;(IPC1-7):C07K13/00;C07K15/04;A61K37/02 |
主分类号 |
C07K14/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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