Biphenylmethane derivative and pharmacological use

摘要

The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. <IMAGE> in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, -S-R7, -SO2-R7, -C 3BOND C-R7 or -(CH2)p-OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, -A1=A2-A3=A4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- or -CH=N-CH=N-, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (-COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.