发明名称 |
NPY peptide analogs |
摘要 |
Human Neuropeptide Y (NPY) has the formula: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro- Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile- Thr-Arg-Gln-Arg -Tyr-NH2. Porcine and rat NPY have the same sequence except for Leu instead of Met in the 17-position. Porcine PYY is homologous having 11 different residues. NPY analogs and N-terminally-shortened fragments, e.g. NPY(18-36), which contain one or more specific D-isomer substitutions for the naturally occurring residues (as well as pharmaceutically acceptable salts thereof), dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to substantially lower blood pressure over an extended period of time or to counteract hypertension.
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申请公布号 |
US5328899(A) |
申请公布日期 |
1994.07.12 |
申请号 |
US19920882923 |
申请日期 |
1992.05.12 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BOUBLIK, JAROSLAV H.;RIVIER, JEAN E. F.;BROWN, MARVIN R.;SCOTT, NEAL A. |
分类号 |
A61K38/00;C07K14/575;(IPC1-7):A61K37/02;C07K7/08;C07K7/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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