| 摘要 |
<p>A method of enhancing antigen presentation is disclosed, wherein an antigen is modified by coupling or incorporation with α2-macroglobulin (α2M), a construct thereof, or a reactive fragment thereof. The antigen so prepared is capable of eliciting enhanced immune response from silent, scarce or weak epitopes. This may comprise an actual activation process, a shift in the dominance to a different epitope by reducing recognition of an immunodominant epitope, or another mechanism. Also included are the antibodies which recognize these epitopes, methods of treatment and use, including the preparation of monovalent and polyvalent vaccines, recombinant α2M constructs, and assay techniques and kits for performing such methods.</p> |
