摘要 |
The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R<1> and R<2> i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R<1> and R<2> is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R<1> and R<2> is a single bond; R<3> is preferably hydrogen, halogen or lower alkyl, R<4> is preferably hydrogen or lower alkyl, X is preferably CH2, Y is preferably hydrogen and Z is preferably CONR<14>R<15> and R<14> and R<15> are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations. |
申请人 |
GLAXO INC.;ANDREWS, ROBERT, CARL;CRIBBS, CYNTHIA, MARKERT;FRYE, STEPHEN, VERNON;HAFFNER, CURT, DALE;MALONEY, PATRICK, REED |
发明人 |
ANDREWS, ROBERT, CARL;CRIBBS, CYNTHIA, MARKERT;FRYE, STEPHEN, VERNON;HAFFNER, CURT, DALE;MALONEY, PATRICK, REED |