SUBSTITUTED BUTENOIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

There are provided novel, therapeutically active 4-(4-hydroxy-3-nitrophenyl)-4-oxo-(2E)-butenoic acid and 4-(4-hydroxy-3-nitrophenyl)-4-oxo-(2Z)-butenoic acid of formula (I), as well as their salts formed with H2 receptor antagonists, preferably their Famotidine salt, and pharmaceutical compositions containing these compounds. Furthermore, processes are described for the preparation of the above compounds and compositions, respectively. The compounds of formula (I) and salts thereof possess significant gastric acid secretion inhibitory and gastrocytoprotective activities. Thus, they are useful for the prevention and/or healing of various ulcerous disease of the oesophagus, stomach and duodenum.