发明名称 |
NOVEL DERIVATIVES OF A FIVE-MEMBERED RING FUSED BENZENE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME |
摘要 |
The invention relates to novel, therapeutically active acid, salt, ester and amide derivatives of a 5-membered ring fused benzene of formula (I), wherein R is selected from hydroxy, (C1-4)alkoxycarbonylmethoxy, (C1-4)alkylamino, cyclohexylamino; phenylamino optionally substituted by halogen; (C1-4)alkoxycarbonylmethylamino, 1-(C1-4)alkoxycarbonyl-2-phenylethylamino, pyrrolidino and N-(C1-4)alkoxycarbonylpiperazino; and X stands for oxygen or methylene, with the proviso that X means oxygen when R stands for hydroxy; and their salts formed with H2 receptor antagonists, when X means oxygen and R stands for hydroxy, as well as pharmaceutical compositions containing the above compounds. The invention relates also to a process for the preparation of the above compounds and compositions. The compounds of formula (I) show significant gastrocytoprotective and gastric acid secretion inhibitory activities. In addition, they possess an antibacterial activity against the pathogenic bacterial strain Helicobacter pylori. Thus, they are useful for the prevention and/or healing of various ulcerative diseases of the digestive system (oesophagus, stomach and duodenum). |
申请公布号 |
WO9414788(A1) |
申请公布日期 |
1994.07.07 |
申请号 |
WO1993HU00078 |
申请日期 |
1993.12.17 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT.;HOFFMAN, GYOERGY;DOBAY, LASZLO;FISCHER, JANOS;PERENYI, EVA;EZER, ELEMER;MATUZ, JUDIT;SAGHY, KATALIN;SZPORNY, LASZLO;HAJOS, GYOERGY |
发明人 |
HOFFMAN, GYOERGY;DOBAY, LASZLO;FISCHER, JANOS;PERENYI, EVA;EZER, ELEMER;MATUZ, JUDIT;SAGHY, KATALIN;SZPORNY, LASZLO;HAJOS, GYOERGY |
分类号 |
C07C69/738;C07C235/78;C07D295/205;C07D307/83;(IPC1-7):C07D307/83;A61K31/19;A61K31/34;A61K31/165;A61K31/235;C07C233/11;C07C59/86;C07D295/116 |
主分类号 |
C07C69/738 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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