TETRAHYDROCARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS

摘要

Compounds of formula (I), wherein R<1> represents halogen, C1-4alkyl, C1-4alkoxy, hydroxy, NO2, -NR<4>R<5>, R<4>R<5>NCO(CH2)m-, R<4>R<5>NSO2(CH2)m-, R<6>CONH(CH2)-m or R<7>SO2NH(CH2)m-; R<4> and R<5> each independently hydrogen or C1-4alkyl or NR<>4 represents a 5- to 7-membered heterocyclic ring; R<6> represents hydrogen or C1-4alkyl; R<7> represents C1-4alkyl; m is zero, 1 or 2; n is zero or 1 to 5; R<2> and R<3> each independently represent hydrogen, C1-6alkyl or benzyl or -NR<2>R<3> represents a pyrrolidino, piperidino or hexahydroazepino ring; and A represents a bond, a C1-5alkylene chain or a C3-5alkenyle chain wherein the double bond is not adjacent the nitrogen atom; and salts thereof have affinity for the 5-HT1-like receptor and are useful e.g. in the treatment of migraine.