| 摘要 |
2149777 9414834 PCTABS00032 Steroids of formula (I) where ---- is independently at each of the 1,2-, 4,5- and 6,7-positions, a single or double bond; R1 is a straight- or branched-chain C1-4 alkyl or C2-4 alkenyl; R2 is hydrogen or methyl; R3 is C1-7 alkyl, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl or -CH2R where R is halo, hydroxy, C1-5 alkoxy or C1-10 alkanoyloxy; R4 is hydrogen, halo, hydroxy, keto or C1-3 alkoxy when ---- at the 6,7-position forms a single bond, or hydrogen, halo or C1-3 alkoxy when ---- at the 6,7-position forms a double bond; R5 is hydrogen or halo; R6 is hydrogen when ---- at the 1,2-position forms a single bond or hydrogen or chloro when ---- at the 1,2-position forms a double bond; and n is 0-2; and racemic mixtures and diastereoisomers thereof, processes for their preparation, pharmaceutical compositions containing them, and methods for their use, especially as antiinflammatories.
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