2-(2-SUBSTITUTED PYRROLIDIN-4-YL)THIO-CARBAPENEM DERIVATIVES

摘要

The present invention relates to novel 2-(2-substituted pyrrolidin-4-yl)-thio-carbapenem derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which R1 represents hydrogen or (lower)alkyl, R2 represents hydrogen or anion, R3 represents hydrogen or (lower)alkanimidoyl, Z represents (a) or Rg, X represents O or NH, and R4 and R9 are defined as in claim 1; m is an integer of 1 to 6, provided that when m is 1 and X is 0, R4 is other than unsubstituted amino(-NH2), and to a process for preparation of the novel compound of formula (I) and salts thereof, an intermediate for preparation thereof and its prepartion, an antibacterial composition containing the compound (I) and use of the compound (I) as an antibacterial agent.