发明名称 |
PIPERIDINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS |
摘要 |
Compounds of formula (I): wherein R1 represents C1-6alkyl, halogen or phenyl; R2, represents hydrogen, C1-6alkyl halogen or phenyl; R3 represents hydroxyl or a group convertible thereto in vivo; R4 represents C1-6alkyl; p is zero, 1 or 2; X represents -CH2-, -C ? O, O or S; n is an integer from 4 to 10; m is an integer from 3 to 8; and salts thereof are useful as calcium antagonists, e.g. in the treatment of conditions relating to an accumulation of calcium in brain cells.
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申请公布号 |
CA2152394(A1) |
申请公布日期 |
1994.07.07 |
申请号 |
CA19932152394 |
申请日期 |
1993.12.16 |
申请人 |
SMITHKLINE BEECHAM PLC |
发明人 |
BROWN, THOMAS HENRY;COOPER, DAVID GWYN;KING, RONALD JOSEPH |
分类号 |
C07D295/08;A61K31/445;A61P3/00;A61P3/14;A61P9/08;A61P9/10;A61P25/28;C07D295/092;C07D295/096;C07D295/10;C07D295/108;(IPC1-7):C07D295/096;C07D225/02;C07D205/04;C07D223/04;C07D207/06;C07D211/14;A61K31/395 |
主分类号 |
C07D295/08 |
代理机构 |
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主权项 |
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地址 |
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