| 摘要 |
Compounds of the formula: <IMG> (wherein R1 is hydrogen or alkyl; R2 is an optionally substituted carbocyclic or heterocyclic ring: Z is hydrogen or a group -COR9, (R9 is alkyl or phenyl) <IMG> , <IMG> , <IMG> , <IMG> , <IMG> in which R10 is hydrogen, halogen, trihalomethyl, alkyl or alkoxy, R11 and R12 are each hydrogen, alkyl or phenyl substituted by R10, or R11 and R12 together represent alkylene and p is 1 or 2; q is 1 to 4; A is phenyl or cycloalkyl optionally substituted by halogen, trihalomethyl, alkyl or alkoxy; and m is zero and n is 1 to 4 or n is zero and m is 1 to 4; and non-toxic salts thereof, have an inhibitory effect on enkephalinase and are useful as analgesic, antianxiety and anticonvulsant agents.
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