| 摘要 |
PURPOSE:To obtain a new compound useful as an endothelin antagonistic agent, etc., used for preventing and treating diseases such as hypertension, arteriosclerosis, Reynaud disease or asthma. CONSTITUTION:The substance AM6222A, AM6222B or AM6222C or salt thereof. Furthermore, the substance AM6222A has the following physical properties: color and state of the substance white powder; distinction of acidity, facility and neutrality: an acidic substance; specific rotatory power: [alpha]<23>D-57 deg.+ or -10 deg. (c =0.4, methanol); molecular formula: C52H70O10N2; molecular weight: 882 fast atom bombardment (FAB) mass spectrum [(M+H)<+> 883.5066]; elementary analysis: calculated (%): C, 70.72; H, 7.99 and N, 3.17; found (%): C, 70.81; H, 8.02 and N, 3.16; solubility: soluble in methanol, dimethylsulfoxide and alkaline water and insoluble in water, benzene and n-hexane; UV spectrum: 218, 266 and 300-310 (nm)(main absorption peaks); IR spectrum: shown in the figure. The substance AM6222A is obtained by culturing a microorganism, belonging to the genus Stachybotrys and capable or producing the substance AM6222A (FERM P-13344) under aerobic conditions. |
