Imidazopyridines

摘要

Imidazopyridine derivatives of the formula I in which R is R<1> is C3-C7-cycloalkyl-CnH2n- or C1-C6-alkyl, in which a CH 2 group is replaced by O or S, R<2> is H, COOR<6>, CN, NO2, NH2, NHCOR<5>, NHSO2R<5> or 1H-5-tetrazolyl, R<3> is -CmH2m-CN, C2-C6-alkynyl, -CmH2m-Ar, -CmH 2m-CO-R<5>, -CmH2m-CO-Ar, -CmH2m-Het or -CmH2m-CO-Het, R<4> is H or Hal, R<5> is C1-C6-alkyl, in which one or more H atoms can also be replaced by F, R<6> is H or A, X is missing or is -NH-CO-, -CO-NH-, -O-CH(COOH)-, -NH-CH(COOH)-, -NA-CH(COOH), -CH=C(COOH), -CH=C(CN) or -CH=C(1H-5-tetrazolyl)-, Y is O or S, A is alkyl having 1-6 C atoms, Ar is an unsubstituted phenyl group or a phenyl group which is monosubstituted or disubstituted by Hal, R<5>, OH, OR<5>, COOR<6>, CN, NO2, NH2, NHA, N(A)2, NHCOR<5>, NHCOOA, NHSO2R<5> and/or 1H-5-tetrazolyl, Het is a 5-membered or 6-membered heteroaromatic radical having from 1 to 4 N, O and/or S atoms, which can also be fused with a benzene or pyridine ring, Hal is F, Cl, Br or I, m is 1, 2, 3, 4, 5, or 6 and n is 0, 1, 2, 3, 4, 5 or 6, and also their salts, exhibit angiotensinII-antagonistic properties and may be used for treating hypertension, aldosteronism, cardiac insufficiency and increased intra-ocular pressure, as well as disturbances of the central nervous system.