| 摘要 |
The invention relates to a process for the preparation of diacetylrein having the formula <IMAGE> with an acceptable degree of pharmacological purity, having a residual concentration of undesirable aloemodine derivatives totalling less than 20 ppm. The process is characterised by submitting rein-9-anthrone-8-glycoside containing aloemodine components to liquid-liquid extraction, oxidizing the 1,8-dihydroxyanthrone glucosides to 1,8-dihydroxyanthraquinone glucosides, removing the corresponding glucosyl groups, acetylating the 1,8-dihydroxyanthroquinone compound obtained, recrystallizing the final product and drying the latter so as to obtain a product with a better appearance. The invention also relates to diacetylrein itself obtained by this process, and a pharmaceutical composition which contains this compound as the active ingredient.
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