1-Phenylbicyclo[2.2.2]octane compounds process for preparing them and pharmaceutical compositions containing them

摘要

Compound of formula (I): in which: R1 denotes a halogen atom or a hydroxyl, alkyl, alkoxy, cyano, amino, mercapto, alkylthio or phenoxy group, R2 and R'2 denote two hydrogen atoms when the ring is unsaturated, or else, being identical or different, denote a hydrogen or halogen atom or a hydroxyl, alkyl, alkoxy, cyano, amino or oxo group when the ring is saturated, R3 denotes any one of the following groups: . - CO2H . - CO-NH-CH2-CO2H . - . - (CH2)m-CO2H . - in which m denotes 1, 2 or 3, X denotes an oxygen or sulphur atom or a group N-R, R5 or R6, which are identical or different, denote a hydrogen atom, an alkyl or trifluoromethyl group or form a C3-C6 cycloalkyl radical, n denotes 0, 1 or 2, R7 denotes a hydroxyl, alkoxy, amino or -O-CH2-CO-NRR' group, . or any one of the heterocyclic rings as defined in the description, R4 denotes a hydrogen or halogen atom or an alkyl, alkoxy or trihaloalkyl group. Medications.