N-(2'aminophenyl)-benzamide-derivatives, process for their preparation and their use in the control of neoplastic diseases

摘要

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE N-2'-(aminophenyl)-benzamide derivatives of the general formula II see diagramm : EP0242851,P12,F5 wherein R is an unsubstituted C1 -C4 acylamino group or one substituted with hydroxyl. 1. Claims for the Contracting States : AT, ES, GR Process for the preparation of N-2'-(aminophenyl)-benzamide derivatives of the general formula II see diagramm : EP0242851,P13,F5 wherein R is an unsubstituted C1 -C4 acylamino group or one substituted with hydroxyl, characterised in that a compound of the general formula IIIa see diagramm : EP0242851,P14,F1 in which R has the same meaning as above and A is a reactive acid group, is reacted with a compound of the general formula IIIb see diagramm : EP0242851,P14,F2 in which X is an amino group provided with a protective group or is a nitro group, in a manner known per se, the compounds thus obtained of the general formula IV see diagramm : EP0242851,P14,F3 in which X and R have the same meaning as above, are reduced or, by splitting off the protective group, are converted into the corresponding compounds of the general formula II.