发明名称 |
Process for the preparation of (6S)- and (6R)-tetrahydrofolic acid |
摘要 |
For the preparation of (6S)- and (6R)-tetrahydrofolic acid and their addition salts with a sulfonic acid or with sulfuric acid, (6R,S)-tetrahydrofolic acid is reacted with a sulfonic acid or with sulfuric acid, the resulting acid addition salt is fractionally crystallized and, if desired, the (6S)- or (6R)-tetrahydrofolic acid is liberated from the resulting diastereomeric acid addition salts by treatment with a base and isolated.
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申请公布号 |
US5324836(A) |
申请公布日期 |
1994.06.28 |
申请号 |
US19930044886 |
申请日期 |
1993.04.08 |
申请人 |
EPROVA AKTEINGESELLSCHAFT |
发明人 |
MUELLER, HANS R.;ULMANN, MARTIN;CONTI, JOSEF;MUERDEL, GUENTER |
分类号 |
C07B57/00;C07D475/04;(IPC1-7):C07D475/04 |
主分类号 |
C07B57/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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