发明名称 |
Oxidization metabolites of 5- alpha -23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione |
摘要 |
The compounds of formula (I) <IMAGE> wherein R is selected from the group hydroxymethyl and carboxy, have been identified as metabolites of 5 alpha -23-methyl-4-aza-21-nor-chol-1-ene-3,20-dione and are believed to be active as testosterone 5 alpha -reductase inhibitors and would thus be useful for treatment of acne, seborrhea, female hirsutism or benign prostatic hypertrophy.
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申请公布号 |
US5324734(A) |
申请公布日期 |
1994.06.28 |
申请号 |
US19920945204 |
申请日期 |
1992.09.15 |
申请人 |
MERCK & CO., INC. |
发明人 |
GILBERT, JOHN D.;OLAH, TIMOTHY V. |
分类号 |
C07J73/00;(IPC1-7):C07D221/02;A61K31/47 |
主分类号 |
C07J73/00 |
代理机构 |
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地址 |
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