| 摘要 |
A system for selective removal of certain components from plasma drawn from a patient comprises an extracorporeal blood circulation circuit and a cannula. The extracorporeal blood circulation circuit has an uptake line for transporting blood from the patient, a plasma separator, and a return line connected to the plasma separator for transporting selectively depleted blood from the plasma separator to the patient. The plasma separator is connected to the uptake line for receiving the blood, selectively removing plasma components (e.g., heparin) by separating plasma from whole blood and interfacing such plasma with an adsorption substrate, recombining depleted plasma, and reinfusing selectively depleted blood into the return line for transport to the patient. The cannula has an uptake conduit with an intake end and an exit end, and a return conduit, connected to the uptake conduit, with an outflow end and an entry end. The exit end is connected to the uptake line of the bypass circuit and the entry end is connected to the return line of the bypass circuit. Structure at the outflow end of the return conduit alters the direction of flow and directs selectively depleted blood being returned to the patient into the right atrium of the patient's heart when the intake end of the uptake conduit is disposed within the patient's inferior vena cava. An alternative cannula with washers may be inserted into a venous return cannula whereby recirculation and pooling of the selectively depleted blood is prevented. |
