A contrast agent useful for imaging a sample comprising a suspension in a medium acceptable for imaging (a) particles of a contrast agent possessing paramagnetic characteristics and (b) particles of a contrast agent possessing diamagnetic characteristics. Also disclosed is a method of imaging a sample which comprises introducing into the sample the above-described contrast agent and generating a substantially artifact-free image thereof. The combination of diamagnetic barium sulfate and superparamagnetic iron oxide (SPIO) in one suspension produces a macroscopic cancellation of positive and negative magnetic susceptibility components which eliminates susceptibility artifacts even with gradient echo pulse sequences. The relaxation properties which make the SPIO suspension a useful negative contrast agent are retained.
申请公布号
US5323780(A)
申请公布日期
1994.06.28
申请号
US19920925549
申请日期
1992.08.07
申请人
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人
BRIGGS, RICHARD W.;LIEBIG, THOMAS;ROS, PABLO R.;BALLINGER, J. RAY