| 摘要 |
<p>The present invention relates to 2-debenzoyl-2-acyl taxol derivatives, analogues thereof and methods for making same. Compounds of the present invention include compounds having the general formula: <CHEM> wherein R1 is an alkyl or substituted alkyl; R2 is selected from the group consisting of H and C(O)Ra; R3 is selected from the group consisting of H, protecting groups, Rb, and C(O)Rb; R4 is selected from the group consisting of H and C(O)Rc, and wherein Ra, Rb, and Rc are independently selected from the group consisting of alkyls, substituted alkyls, alkenyls, alkynyls, aryls, and substituted aryls; provided that Ra is other than phenyl and 3-hydroxyphenyl.</p> |
