| 摘要 |
<p>Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -E-G- is a bivalent radical of formula -X-C(R1)$(1,3)$CH- (a-1); or -CH$(1,3)$C(R2)-X- (a-2); X represents O, S or NR3; R3 represents hydrogen, C¿1-6?alkyl or C1-4alkylcarbonyl; -B$(1,3)$D- is a bivalent radical of formula -C(R?4¿)$(1,3)$N- (b-1); or -N$(1,3)$C(R5)- (b-2); L represents hydrogen; C¿1-6?alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het?1¿ (c-1), -Alk-NH-CO-Het2 (c-2) or -Alk-Het3 (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.</p> |
