| 摘要 |
Antiallergic imidazo¢1,2-a!(pyrrolo, thieno or furano)¢2,3-d!azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; R1 represents hydrogen, C1-4alkyl, halo, ethenyle substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl, hydroxycarbonyl or hydroxycarbonylC1-4alkyl; R2 represents hydrogen, C1-4alkyl, ethenyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, C14alkyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl or hydroxycarbonyl; R3 represents hydrogen, C1-4alkyl, hydroxyC1-4alkyl, phenyl or halo; X represents O, S or NR4; L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or a radical of the formula: -Alk-Y-Het1 (a-1), -Alk-NH-CO-Het2 (a-2) or Alk-Het3 (a-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.
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