New pyrrolo-prostacyclin derivs

摘要

Pyrroloprostacyclin derivs of formula (I), their salts, alpha-, beta- and gamma-cyclodextrin clathrates and liposome-encapsulated forms are new:R1 = COOR2 or CONHR3; R2 = H; 1-4C alkyl; or CH2CO-aryl; R3 = H; 1-10C alkanoyl or alkanesulphonyl; or 2H-tetrazol-5-yl; R4 = H or opt. functionally modified OH; A = trans -CH=CH- or -C=C-; W = opt. functionally modified HO-CH2-; D = a gp. of the formula (i); or opt. unsatd. alkylene with up to 5C; E = a direct bond, -CH=CH- -C=C- -C=C-; or O; or D and E together are a direct bond; R5 = 1-10C alkyl; 3-10C cycloalkyl opt. substd. by 1-4C alkyl; or Ph opt. mono-substd. b F, Cl or CF3; n = 1 or 3.