ANTITUMOUR AGENTS

摘要

Novel mitosenes useful as antitumour agents are compounds of formula (II) in which R1 and R2 together with the nitrogen to which they are attached represent a cyclic or acylic secondary amine, R3 is hydrogen or an alkyl group, R4 and R5 are each independently hydrogen or an alkyl group and Z is a leaving group, or a salt thereof.