发明名称 |
MULTIVALENT AND MULTISPECIFIC BINDING PROTEINS, THEIR MANUFACTURE AND USE |
摘要 |
Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to form an antigen binding site, associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains may be linked by a short peptide linker or may be joined directly together. Bispecific dimers may have longer linkers. Methods of preparation of the polypeptides and multimers and diverse repertoires thereof, and their display on the surface of bacteriophage for easy selection of binders of interest, are disclosed, along with many utilities.
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申请公布号 |
CA2150262(A1) |
申请公布日期 |
1994.06.23 |
申请号 |
CA19932150262 |
申请日期 |
1993.12.03 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
HOLLIGER, KASPAR-PHILIPP;GRIFFITHS, ANDREW DAVID;HOOGENBOOM, HENDRICUS RENERUS JACOBUS MATHEUS;MALMQVIST, MAGNUS;MARKS, JAMES DAVID;MCGUINNESS, BRIAN TIMOTHY;POPE, ANTHONY RICHARD;PROSPERO, TERENCE DEREK;WINTER, GREGORY PAUL |
分类号 |
G01N33/531;A61K38/00;A61K39/395;C07K1/00;C07K2/00;C07K16/00;C07K16/46;C07K19/00;C12N1/21;C12N15/09;C12N15/10;C12N15/113;C12N15/13;C12N15/62;C12N15/70;C12P21/02;C12P21/08;C12R1/19;C40B40/02;(IPC1-7):C12N15/13;C12N7/01;G01N33/53 |
主分类号 |
G01N33/531 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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