发明名称 |
DNA-ARMED RIBOZYMES AND MINIZYMES |
摘要 |
The invention describes catalytic nucleic acid based compounds capable of cleaving nucleic acid polymers both in vivo and in vitro. Two embodiments of this invention are compounds with a short stem that does not base pair, a minizyme, and compounds with DNA hybridizing arms and RNA catalytic domain and stem, DNA-armed ribozymes. The compounds of this invention, while nucleotide based may be substituted or modified in the sugar, phosphate, or base. Methods of use and methods of treatment are also described. |
申请公布号 |
WO9413688(A1) |
申请公布日期 |
1994.06.23 |
申请号 |
WO1993AU00630 |
申请日期 |
1993.12.08 |
申请人 |
GENE SHEARS PTY. LIMITED;JENNINGS, PHILIP, A.;MCCALL, MAXINE, J.;HENDRY, PHILIP |
发明人 |
JENNINGS, PHILIP, A.;MCCALL, MAXINE, J.;HENDRY, PHILIP |
分类号 |
A61K38/00;C07H21/00;C12N9/22;C12N15/113;(IPC1-7):C07H21/02;C07H21/04;C12N5/10;C12N15/63;C12N15/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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