METHODS FOR IDENTIFYING AND USING IMMUNOSUPPRESSANT COMPOUNDS

摘要

A method of identifying a potential immunosuppressive agent by assaying for the ability of a given candidate compound to inhibit T cell activation via the activation pathway involving stimulation by (i) a substance which stimulates the T cell CD28 antigen, and (ii) a phorbol ester; and use of such immunosuppressive agents to treat patients in need of immunosuppression.