| 摘要 |
<p>A method for prolonged delivery of a therapeutic agent to the eye is disclosed. The method provides for the addition of a desired drug to a suitable, preferably non-aqueous, carrier. An amount of the carrier containing the therapeutic dose of the drug is placed on the skin exterior to the ocular surface near the lateral and lower lid margins. Movements of the orbicularis oculi associated with the scissor-like closing of the lids of the eye continuously transport small portions of the therapeutic agent and carrier into the interpalpebral space where the drug is released to the corneal surface. Further provided is a calcium-based ophthalmic composition which is particularly effective in treating dry eye syndrome and which is optimally delivered by the method just described.</p> |
