STABLY TRANSFECTED CELL LINES EXPRESSING GABA-A RECEPTORS

摘要

The present invention relates to a stably co-transfected eukaryotic cell line capable of expressing a human GABAA receptor, which receptor comprises the alpha 1 beta 3 gamma 2, alpha 2 beta 3 gamma 2, alpha 5 beta 3 gamma 2, alpha 1 beta 1 gamma 2S, alpha 1 beta 2 gamma 2, alpha 3 beta 3 gamma 2 or alpha 6 beta 3 gamma 2 subunit combination; to membrane preparations derived from cultures thereof; and to the use of the cell line in designing and developing GABAA receptor subtype-selective medicaments.