1,4-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS CCK-MODULATORS

摘要

Compounds of general formula (I) and physiologically acceptable salts thereof; wherein R1 represents CH2CONR5R6 or CH2COR7; R2 represents a phenyl group optionally substituted by 1 or 2 substituents selected from halogen, alkyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, amino, substituted amino, hydroxy, alkoxy, methylenedioxy, alkoxycarbonyl, oxazolyl or oxadiazolyl; A represents a C1-4 straight or branched alkylene chain; R3 and R4 independently represent hydrogen or C1-4alkyl or R3 and R4 together with the nitrogen atom to which they are attached form a saturated 5-7 membered heterocyclic ring, which ring may contain an additional heteroatom selected from oxygen, sulphur or nitrogen; R5 represents hydrogen or C1-4alkyl; R6 represents C1-4alkyl or phenyl, optionally substituted by halogen, or R5 and R6 together with the nitrogen atom to which they are attached represent a saturated 5 to 7 membered heterocyclic ring which may be optionally substituted by 1 or 2 methyl groups or fused to a benzene ring; R7 represents a group selected from C1-4alkyl, or optionally substituted phenyl; R8 represents hydrogen or a halogen atom; n is zero, 1 or 2, are antagonists of gastrin and CCK.