| 摘要 |
Compound having general formula (I) wherein one of X and Y is CH2 and the other one is CH2, O or S; R<1> is an aliphatic hydrocarbon group, arylalkyl, acyl, a sulphonyl group, a carbonate group or R<11>R<12>NCO- where R<11> and R<12> are selected form hydrogen and a hydrocarbon group; R<2> is hydrogen or a hydrocarbon group; R<3>-R<5> are independently selected from hydrogen, halogen, alkyl, alkoxy, alkylthio, hydroxy, alkylsulphonyl, cyano, trifluoromethyl, cycloalkyl, cycloalkylalkyl or nitro; R<6> and R<7> are each hydrogen or lower alkyl or they are linked together to constitute a carbocyclic ring; R<8> and R<9> are independently hydrogen, a hydrocarbon group or a group 1a wherein R<13> is hydrogen, or a hydrocarbon group, W is O or S, and r is 2-6; R<8> and R<9> are linked together thereby forming alkylene group; have effect at central 5-HT1A receptors and are useful in the treatment of psychosis, anxiety disorders, depression, impulse control disorders, alcohol abuse, aggression, ischaemic diseases, side effects induced by conventional antipsychotic agents or cardiovascular disorders. |
