| 摘要 |
A method of preparing a pharmaceutical formulation of an active substance which is insoluble in conventional solvents, comprising co-dissolving the active substance and an amphipathic lipid in an organic acid or acid anhydride and then removing or neutralising the acid or acid anhydride. The resulting formulations may be liposomal or alternatively may take the form of lipid suspensions in aqueous solution or lipid-water gels. Active substances such as albendazole, which are sparingly soluble in conventional solvents, are particularly suited to formulation by the method of the invention. |
