Protective role of polyamines in modifications of basement membrane macromolecules

摘要

Polyamines including putrescine are found to interfere with nonenzymatic glucosylation, interfere with formation of advanced glucosylation end-products by minimizing crosslink formation and act as a reducing agent to minimize oxidative damage to proteins. These polyamines are useful in treating diabetics to minimize damage caused by the high glucose concentrations and to reduce cross-linking-mediated or oxidation-mediated tissue aging.