发明名称 |
POLYNUCLEOTIDE HAVING NUCLEOTIDE SEQUENCE FOR CODING PROTEIN OF OUTER LAYER FILM OF MENINGOCOCCUS AND VACCINE COMPOSITION |
摘要 |
The present invention is concerned with a method for the isolation of a nucleotide sequence which codes for a protein having a molecular weight of about 64 000 daltons, which is located on the outer membrane of N. meningitidis, as well as with the recombinant DNA obtained therefrom, which is used for the transformation of a host microorganism. The technical object pursued with the invention is the identification of a nucleotide sequence coding for a highly conserved and common protein for the majority of pathogenic Neisseria strains, the production of this protein with a high level of purity and in commercially useful amounts using the recombinant way, so that it can be used in diagnostic methods and vaccine preparations with a broad immunoprotection spectrum. <IMAGE> |
申请公布号 |
JPH06169779(A) |
申请公布日期 |
1994.06.21 |
申请号 |
JP19910255872 |
申请日期 |
1991.09.07 |
申请人 |
CENTRO DE INHENIERIA HENETEIKA I BIOTEKUNOROHIA |
发明人 |
RITSUKARUDO SHIRUBA RODORUGESU;MANIYUERU SERUMAN FUSEIN SOSA;GERARUDO GIREN NIETO;RUISU SATOURUNIINO ERERA MARUTEINESU;JIYURIO RAURU FUERUNANDESU MASO;RIDEIA INESU NOBOA PERESU;JIYUAN MORARESU GURIRO;BIBIAN MORERA KORUDOBA;SONIA GONTSUARESU BURANKO;BEATORISU TAMARUGO SANTOSU;HESASU AUGUSUTO DERU BARE ROZARESU;EBERIN KABARERO MENENDESU;ANABERU ARUBARESU AKOSUTA;EDERUGISU KUZO RODORIGESU;SHIRIAN KURUSU REON;AREKUSHISU MUSATSUCHIO RASA |
分类号 |
A61K39/095;A61K39/00;A61K39/395;A61P31/04;C07K14/00;C07K14/195;C07K14/22;C07K14/41;C07K16/00;C07K16/12;C07K16/40;C07K19/00;C12N1/21;C12N9/02;C12N9/10;C12N15/00;C12N15/09;C12N15/31;C12N15/53;C12N15/54;C12N15/70;C12P21/02;C12P21/08;C12R1/19;(IPC1-7):C12N15/31;C07K13/00 |
主分类号 |
A61K39/095 |
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