| 摘要 |
Imidazole derivatives of general formula I <IMG> (I) wherein R1 means hydrogen, an optionally substituted C1-10 hydrocarbon or hetaryl residue, or a cyclic ether residue, R2 means hydrogen, halogen, an optionally substituted amino, nitro, azide, thiocyanate or cyano group, a linear or branched C1-10-alkyl residue optionally substituted with halogen, or -OR1 wherein R1 has the above-mentioned meanings, and R1 and R2 jointly with the oxygen atom form a saturated or unsaturated 5- to 7-membered ring which can contain still another hetero atom, R3 means hydrogen, a linear or branched C1-6- alkyl group, or a C1-6-alkoxyalkyl group, R4 means -COOR5, -CONR6R7, -CN, <IMG> or <IMG> R5 meaning hydrogen, a linear or branched C1-6-alkyl group, R6 and R7 being identical or different and representing hydrogen or a linear, branched or cyclic alkyl group of up to 7 carbon atoms, or jointly with the nitrogen atom forming a saturated five- or six-membered ring that optionally contains a further hetero atom, R8 meaning hydrogen or linear, branched or cyclic akyl group of up to 7 carbon atoms, wherein R2 can be present singly or severally at the phenyl residue, are disclosed, as well as the process for their production, and their use as agonists, inverse-agonists and antagonists for benzodiazepines, and psychopharmaceuticals, especially anxiolytics.
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