Liquid-suspension controlled-release pharmaceutical composition.

摘要

Disclosed is a liquid-suspension controlled-release enteric-coated pharmaceutical formulation for the administration of naproxen, comprising (a) microgranules of naproxen and an excipient; (b) four successive coatings of polymeric hydrophilic and hydrophobic materials, the first applied of said coatings imparting controlled-release properties to said naproxen according to a predetermined release profile; and (c) a liquid administration vehicle. This composition enables the oral administration of naproxen as a single daily dose and the adjustment of the dosage to a patient's requirements, thus aiding oral intake and minimizing the drug's typical side effects.