| 摘要 |
METHOD FOR RENDERING A SYSTEM IMMUNOLOGICALLY COMPATIBLE UTILIZING A NUCLEIC ACID CONSTRUCT. A NUCLEIC ACID CONSTRUCT FOR INHIBITING OR REGULATING THE FUNCTION OF AN IMMUNE RESPONSE (Ir) GENE AND AN IMMUNOLOGICALLY COMPATIBLE SYSTEM CONTAINING A NUCLEIC ACID CONSTRUCT FOR INHIBITING OR REGULATING THE FUNCTION OF AN IMMUNE RESPONSE (Ir) GENE This invention provides a method for preparing an immunologically compatible system, e.g., organism, organ, tissue, or cells, by appropriate genetic intervention which can take the form of introducing into the cells of such a system, a nucleic acid construct which, when present in a cell, inhibits or regulates the function of an immune response (Ir) gene or genes in the system. The nucleic acid construct can be introduced, for example, in the form of genetic antisense or as antisense oligos. Also provided by the present invention is such a nucleic acid construct and an immunologically compatible system containing such a nucleic acid construct. When present in a cell, the nucleic acid construct inhibits or regulates the function of an immune response gene or genes in the system. This invention is useful and applicable in the field of therapeutics, and transplantation and transfusion methodologies.
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