摘要 |
A process for preparing clavulanic acid and other clavam derivatives from any one of S-arginine, compounds of formula (I), wherein R<1> is (a) or (b), wherein R<2> = H or C1-6alkyl; compounds of formula (II), wherein R<1> is (c) or (d), where R<2> = H or C1-6alkyl or compounds of formula (III), wherein R is H or OH and wherein R<1> is (e) or (f), where R<2> = H or C1-6alkyl, using an enzyme system from Streptomyces, preferably S. Clavuligerus. |
申请人 |
SMITHKLINE BEECHAM PLC;BAGGALEY, KEITH, HOWARD;NICHOLSON, NEVILLE, HUBERT;ELSON, STEPHEN, WILLIAM;EDWARDS, JEFFREY;EARL, ALISON, JANE;HOLMS, WILLIAM, HENRY;MOUSDALE, DAVID, MICHAEL;BALDWIN, JACK, EDWARD;SCHOFIELD, CHRISTOPHER |
发明人 |
BAGGALEY, KEITH, HOWARD;NICHOLSON, NEVILLE, HUBERT;ELSON, STEPHEN, WILLIAM;EDWARDS, JEFFREY;EARL, ALISON, JANE;HOLMS, WILLIAM, HENRY;MOUSDALE, DAVID, MICHAEL;BALDWIN, JACK, EDWARD;SCHOFIELD, CHRISTOPHER |