ANTIVIRAL AGENTS

摘要

Heteropolytungstates having anti-flaviviral activity having the general formulae (I) to (VII): (I) An[XW12O40] wherein X is selected from P, Si, Ge, Co, Co, Zn, Cu, B, H2, Al, Fe, V, Ga, Mn, C. (II) An[X2W18O62] wherein X is P; (III) An[XW11O39] wherein X is selected from P, Si, Ge, B, Al, Ga, Fe, Co; (IV) An[XW9O34] wherein X is selected from P, Si, Ge; (V) An[X2W17-mMmO61] wherein X is P, M is Mo, and m is 0, 1, 2, 4, or 5; (VI) An[X2W15-mMmO56] wherein X is P, M is V or Mo, and m is 0 or 1; (VII) An[XM2W9O39] wherein X is P, and M is Zr; and wherein in each of the general formulae (I) to (VII), A is a cation, and n is the number of cations necessary for electrical neutrality of the molecule; or dimers, hydrates or pharmaceutically acceptable derivatives thereof. Pharmaceutical compositions and methods for the treatment or prophylaxis of a flaviviral-associated infection which involve the use of these compounds are also disclosed.