IPNV VACCINE

摘要

The invention provides a synthetic polypeptide having at least one antigenic property of at least one strain of infectious pancreatic necrosis virus, said polypeptide consisting substantially of an amino acid sequence selected from formulae (I) to (IX): formula (I) (which contains Seq. ID No: 1) X-Thr-Thr-Asn-Pro-Gln-Asp-Lys-Val-Asn-Asn-Gln-Y; formula (II) (which contains Seq. ID Nos: 2 or 3) X-Thr-Asp-Phe-R1-Ser-Asp-Leu-Pro-Thr-Ser-Lys-Ala-Trp-Gly-Y; formula (III) (which contains Seq. ID No: 4) X-Pro-Thr-Ser-Lys-Ala-Trp-Gly-Trp-Arg-Asp-Y;fFormula (IV) (which contains Seq. ID No: 5) X-Thr-Lys-Tyr-Gly-Lys-Tyr-Asp-Pro-Glu-Gly-Y; formula (V) (which contains Seq. ID No: 6) X-Leu-Glu-Val-Ser-Glu-Ser-Gly-Ser-Gly-Y; formula (VI) (which contains Seq. ID Nos: 7 or 8) X-Gln-Glu-Thr-Ser-Ser-Tyr-R2-Leu-Glu-Val-Ser-Glu-Ser-Gly-Y; formula (VII) (which contains Seq. ID Nos: 9 or 10) X-Ser-Arg-Phe-Thr-Pro-Ser-Gly-Asp-R3-Y; and formula (VIII) (which contains Seq. ID Nos: 11 or 12) X-Pro-His-Gln-Glu-Pro-Ala-Pro-R4-Phe-Tyr-Y; formula (IX) (which contains Seq. ID Nos: 13, 14, 15 or 16) X-Pro-Gln-Gly-R5-Gln-Ser-Met-Asn-Gly-Ala-R6-Y, wherein R1 is Ser or Thr; R2 is Thr or Asn; R3 is Asp-Gly or Asn-Ala; R4 is Asp-Asp or Glu-Glu-; R5 is Pro or Leu; R6 is Arg or Lys; and X and Y may each independently be absent or independently be one or more amino acid residues, useful for the treatment of IPNV infection in fish.