PROCESS FOR PRODUCING PLASMINOGEN-CONTAINING COMPOSITION

摘要

This invention provides a process for producing a plasminogen-containing composition having improved safety as a pharmaceutical preparation, in which the loss of plasminogen activity is minimized and contaminated viruses are inactivated efficiently. The process for producing a plasminogen-containing composition in which viruses are inactivated comprises (1) contact-treating a plasminogen-containing composition having a possibility of viral contamination with trialkyl phosphate under a liquid condition and (2) removing the trialkyl phosphate. Preferably, the trialkyl phosphate contact treatment is carried out under a slightly acidic condition or the process further comprises the steps of (3) lyophilizing and (4) heat-treating the plasminogen-containing composition under a dry condition.