| 摘要 |
<p>A pulmonary hypertension remedy containing an active ingredient comprising a compound represented by general formula (I) or, if it can form a salt, a pharmaceutically acceptable salt thereof, both of which have a potent pulmonary hypertension resistance and are reduced in toxicity, thus being useful for treating pulmonary hypertension, wherein A represents OH or OC(O)CH3-nXn (wherein X represents fluorine, chlorine, bromine, methyl or methoxy; and n represents an integer of 0 to 3) or A may be combined with B to represent a bond; B represents hydrogen or may be combined with A to represent a bond; when R1 represents hydrogen, then R2 represents hydrogen, C(Z)CH¿3-n?Xn (wherein Z represents oxygen or sulfur) or C(Z)NHCH3-nXn; when R?1¿ does not represent hydrogen, then R?1 and R2¿ are combined together to represent (CH¿2?)m (wherein m represents 4 or 5), (CH2)m-1 C(Z), N(R?5)(CH¿2)2C(Z) (wherein R5 represents hydrogen or methyl), (CH¿2?)m-2NHC(Z) or (CH2)m-2OC(Z); and R?3 and R4¿, which may be the same or different from each other, each represents hydrogen or C¿1?-C4 alkyl, or alternatively R?3 and R4¿ are combined together to represent 1,4-butylene or 1,5-pentylene which may be each substituted by C¿1?-C4 alkyl.</p> |
