发明名称 |
INJECTABLE COMPOSITION |
摘要 |
A composition of taxol and polyethoxylated castor oil is pH balanced to have a pH less than 8.1 to improve stability. This composition can include an acid, preferably citric acid, to adjust the pH value. The invention includes a method of formulating a taxol solution for injection by mixing an acid with a carrier material, such as castor oil, to form a carrier solution after which taxol is mixed with the carrier solution to form the taxol solution at a pH of less than 8.1. |
申请公布号 |
WO9412030(A1) |
申请公布日期 |
1994.06.09 |
申请号 |
WO1993US11199 |
申请日期 |
1993.11.18 |
申请人 |
NAPRO BIOTHERAPEUTICS, INC. |
发明人 |
CARVER, DAVID, R.;PROUT, TIMOTHY, R.;EWALD, HERNITA |
分类号 |
C07D305/14;A01D43/02;A01N43/02;A61J1/00;A61K9/00;A61K9/08;A61K31/335;A61K31/337;A61K47/02;A61K47/10;A61K47/12;A61K47/14;A61K47/44;(IPC1-7):A01N43/02 |
主分类号 |
C07D305/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|