Combination of Atovaquone with Proguanil for the Treatment of Protozoal Infections

摘要

The invention relates to combinations of atovaquone and proguanil, their use in the treatment and prophylaxis of parasitic infections, such as protozoal parasitic infections, e.g. malaria and toxoplasmosis, and infections caused by P.carinii and their use in the manufacture of medicaments for the treatment and/or prophylaxis of such infections. The combinations can conveniently be administered in a single pharmaceutical formulation. Preferably, atovaquone and proguanil are administered in a potentiating ratio so that they act in synergy.