Composition protective against (p. multocida) pasteurellosis infection

摘要

The invention provides vaccines and methods for protecting an animal against P. multocida associated pasteurellosis. A vaccine of the invention can be comprised of a stable avirulent immunogenic P. multocida mutant or a recombinantly produced P. multocida virulence factor. The avirulent immunogenic mutant can be a transposon-mediated mutant or a mutant having at least one genetically modified virulence gene. The methods of the invention include steps of producing an avirulent immunogenic mutant and administering an effective amount of the mutant to protect an animal against P. multocida pasteurellosis.