发明名称 Method of causing selective immunosuppression using hl-60-related lectins
摘要 Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a frequent thereof. The lectin or fragment binds beta -galactoside-containing moieties independent of the presence or absence of Ca<+2>, stimulates hemagglutination of trypsinized rabbit erythrocytes in standard lectin assays wherein the stimulation is inhibited by lactose or thiogalactoside, has an amino acid sequence containing at least one N-glycosylation site and is at least 90 % homologous to the amino acid sequence shown in positions 2-135 of Figure 1 or the relevant portions thereof. The composition is used for treatment of autoimmune conditions such as rheumatoid arthritis, myasthenia gravis, and multiple sclerosis, as well as modulating the immune response in allergic reactions or to organ or tissue transplant rejection. The inventive composition can be combined with general immunosuppressants.
申请公布号 AU5608594(A) 申请公布日期 1994.06.08
申请号 AU19940056085 申请日期 1993.11.16
申请人 INCYTE PHARMACEUTICALS INC. 发明人 JEFFREY J SEILHAMMER;GLENN NEDWIN;TIM BRINGMAN;PIERRE-OLIVIER COURAUD
分类号 A61K38/00;A61K38/16;A61K39/395;A61K47/48;C07K14/47 主分类号 A61K38/00
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